植物病理教研室
张静柏
作者:编辑:发布时间:2017-02-22

                             

基本信息


姓名: 张静柏 出生年月: 1979.9

性别: 硕/博导: 硕导

民族: 开设课程: 植物病害流行学、农业植物病理学

职称: 副教授 研究方向: 赤霉菌与小麦互作

学位: 农学博士


联系方式
电子邮件:jingbozhang@mail.hzau.edu.cn


个人简介

张静柏,女,1979年生,博士,华中农业大学大阳城2021集团娱乐在线-官网网站教师。1998-2002年就读于于河北农业大学植物保护专业,2002-2008年就读于华中农业大学攻读植物病理学专业博士学位,20081月获农学博士学位,毕业留校任教,承担《农业植物病理学》、《农业植物病理学实验》、《植物病害流行学》、《园林植物病理学》等课程教学。20176-20186月在美国麻省大学阿默斯特分校进行访学研究。从事赤霉菌分子生物学、赤霉菌及其毒素特异抗体分离与毒素分析检测、小麦抗赤霉菌及毒素分子育种等方面研究,主持相关国家自然基金青年科学基金、教育部高等学校博士学科点专项新教师基金、武汉市科技攻关计划项目各1项,曾作为主要参与者完成国家“973”、“中德国际合作重点项目”多个国家课题,现作为骨干力量参加国家重大科技专项-转基因新品种培育1项、国家重点研发计划项目1项,共计发表研究论文40余篇(SCI论文30余篇),授权或申请专利15项,其中国际专利1项。


科研项目

1. 横向项目,湖北省小麦赤霉病菌毒素检测及新型抗病资源的开发,项目年限:2018-2020,(主持)

2. 科技部,国家重点研发计划,湖北麦区小麦化肥农药增效减施技术集成研究与示范,项目年限:2018-2020,(参加)

3. 科技部,国家重大科技专项,抗赤霉病转基因小麦新品系培育,项目年限:2016-2020,(参加)

4. 农业部,国家科技重大专项转基因生物新品种培育项目,高抗赤霉病和毒素转基因小麦新品种培育,项目年限:2014-2016,(参加)

5. 国家自然科学基金青年科学基金项目,赤霉菌致病相关基因CR1 的鉴定和功能分析,项目年限:2013-2015,(主持)

6. 武汉市科技局,武汉市科技计划项目,抗伏马菌素特异重组抗体的分离及应用,项目年限:2013-2014,(主持)

7. 国家自然科学基金面上项目,抗病抗体识别的赤霉病菌表面抗原基因克隆与功能鉴定,项目年限:2013-2016,(参加)

8. 农业部,转基因重大专项,抗赤霉病转基因小麦新品系和新种质创制,项目年限:2011-2015,(参加)

9. 教育部,新教师基金,我国长江中下游小麦、玉米赤霉菌系统群及产毒性比较研究,项目年限:2009-2012,(主持)



教学研究与教学改革

1. 2016年校级教改项目:《植物病害流行学》教学课件PPT的美化与应用(主持)

2. 2016年校级教改项目:《植物病害流行学》教学课件PPT的美化与应用(参加)

       3. 2014年校级教改项目:《农林高校园艺类作物病虫害防治课程教学方法的改革及实践》(参加)




发明专利及获奖情况

部分发明专利:

1. 廖玉才,何伟杰,李和平,易沭远,张静柏,黄涛. 镰刀菌毒素脱毒路径相关基因ADHAKR6D1AKR13B2及其应用. 授权日:2020.08.11

2. Liao, Y.-C., Li, H.-P., Zhang, J.-B., Huang, T., Song, X.-S., Cheng, W., Yang, P. Fusarium chitin synthase gene Chs3b and the use thereof. 授权日:2019.07.16

3. 廖玉才,李和平,张静柏,杨鹏. 一种禾谷镰刀菌葡聚糖合成酶基因GLS及应用. 授权日:2019.12.13

4. 廖玉才;宫安东;李和平;张静柏. 防治作物储藏期黄曲霉菌及毒素的海藻希瓦氏菌及其应用. 授权日:2018.04.10

5. 廖玉才,宫安东,李和平,张静柏. 一株防治小麦赤霉病的解淀粉芽孢杆菌及其应用. 授权日:2017.08.15

6. 廖玉才,李和平,胡祖权,张静柏. 抗伏马菌素B1的单克隆重组抗体H2.授权日:2015.01.28

7. 廖玉才,李和平,胡祖权,张静柏. 抗伏马菌素B1的单克隆重组抗体H7. 授权日:2015.01.28

8. 廖玉才,胡祖权,李和平,张静柏. 镰刀菌特异单链抗体及制备方法和应用.授权日:2014.09.10

9. 廖玉才,王建华,李和平,张静柏,黄涛. 一种镰刀菌单端孢霉烯族A类毒素的分子鉴定方法. 授权日:2014.06.18

10. 廖玉才,王建华,李和平,张静柏,黄涛,瞿波. 玉米赤霉烯酮毒素的分子检测方法及应用. 授权日:2014.04.02

主要奖励:

2014年获得华中农业大学教学质量三等奖


发表的论文及著作

学术论文

第一作者或通讯作者文章

1. Yang, P., Yi, S.-Y., Nian, J.-N., Yuan, Q.-S., He, W.-J., Zhang, J.-B*., Liao, Y.-C*. Application of double-strand RNAs targeting chitin synthase, glucan synthase, and protein Kinase reduces Fusarium graminearum spreading in wheat. Frontiers in Microbiology, 2021, 12: 660976.

2. He, W.-J., Shi, M.-M., Yang, P., Huang, T., Zhao, Y., Wu, A.-B., Dong, W.-B., Li, H.-P., Zhang, J.-B*., Liao, Y.-C*. A quinone-dependent dehydrogenase and two NADPH-dependent aldo/keto reductases detoxify deoxynivalenol in wheat via epimerization in a Devosia strain. Food Chemistry, 2020, 321: 126703.

3. He, W.-J., Shi, M.-M., Yang, P., Huang, T., Yuan, Q.-S., Yi, S.-Y., Wu, A.-B., Li H.-P., Gao C.-B., Zhang J.-B*., Liao Y.-C*. Novel soil bacterium strain Desulfitobacterium sp. PGC-3-9 detoxifies trichothecene mycotoxins in wheat via de-epoxidation under aerobic and anaerobic conditions. Toxins, 2020, 12(6): 363.

4. Gong, A.-D., Sun, G.-J., Zhao, Z.-Y., Liao, Y.-C., Zhang, J.-B*. Staphylococcus saprophyticus L-38 produces volatile, 3-dimethyl-1,2-epoxybutane with strong inhibitory activity against Aspergillus flavus germination and aflatoxin production. World Mycotoxin Journal, 2020: 13 (2): 247-258.

5. Hu, Z.-Q., Li, H.-P., Liu, J.-L., Xue, S., Gong, A.-D., Zhang, J.-B*., Liao, Y.-C. Production of a phage-displayed mouse scFv antibody against Fumonisin B1 and molecular docking analysis of their interactions. Biotechnology and Bioprocess Engineering, 2016, 21: 134-143.

6. Wang, J.-H. #, Zhang, J.-B.#, Li, H.-P., Gong, A.-D., Liao, Y.-C. Molecular identification, mycotoxin production and comparative pathogenicity of Fusarium temperatum isolated from maize in China . Journal of Phytopathology, 2014, 162: 147-157.(共同第一作者)

7. Zhang, J.-B., Wang, J.-H., Gong, A.-D., Chen, F.-F., Song, B., Li, H.-P., Li, X., Peng, C.-H., Liao Y.-C*. Natural occurrence of Fusarium head blight, mycotoxins, and mycotoxin-producing strains of Fusarium in commercial fields of wheat in Hubei. Plant Pathology, 2013, 62: 92-102.

8. Li, X.#, Zhang, J.-B.#, Song, B., Li, H.-P., Xu, H. Q., Qu, B., Dang, F.-J., Liao, Y.-C*. Resistance to Fusarium head blight and seedling blight in wheat is associated with activation of a cytochrome P450 gene. Phytopathology, 2010, 100:183-191.

9. Li, H.-P. #, Zhang, J.-B.#, Shi, R.-P., Huang, T., Fischer, R., Liao, Y.-C. Engineering Fusarium head blight resistance in wheat by expression of a fusion protein containing a Fusarium-specific antibody and an antifungal peptide. Molecular Plant-Microbe Interaction, 2008, 21:1242-1248.

10. Zhang, J.-B., Li, H.-P., Dang, F.-J., Qu, B., Xu, Y.-B., Zhao, C.-S., Liao, Y.-C. Determination of the trichothecene mycotoxin chemotypes and associated geographical distribution and phylogenetic species of the Fusarium graminearum clade from China. Mycological Research, 2007, 111:967-975.

11. 胡祖权,李和平,刘锦龙,吴平,廖玉才,张静柏*. 抗伏马菌素B1单克隆重组抗体的筛选. 基因组学与应用生物学,201534(9)1912-1916

12. 胡祖权,李和平,吴平,廖玉才,张静柏*. 抗镰刀菌单链抗体在大肠杆菌中可溶性表达条件的研究. 生物技术通报,201531(9)238-243

其他作者英文文章

1. Wang, L., Yan Z., Zhou H.-Y., Fan Y.-Y., Wang C., Zhang, J.-B., Liao, Y.-C., Wu, A.-B. Validation of LC-MS/MS coupled with a chiral column for the determination of 3- or 15-acetyl deoxynivalenol mycotoxins from Fusarium graminearum in wheat. Toxins, 2021, 13(9): 659.

2. Guo, M.-W., Yang, P., Zhang, J.-B., Liu, G., Yuan, Q.-S, He, W.-J., Nian, J.-N., Yi, S.-Y, Huang, T., Liao, Y.-C. Expression of microRNA-like RNA-2 (Fgmil-2) and bioH1 from a single transcript in Fusarium graminearum are inversely correlated to regulate biotin synthesis during vegetative growth and host infection, Molecular Plant Pathology, 2019, 20(11): 1574-1581.

3. Song, X.-S., Xing, S., Li, H.-P., Zhang, J.-B., Qu, B., Jiang, J.-H., Fan, C., Yang, P., Liu, J.-L., Hu, Z.-Q., Xue, S., Liao, Y.-C*. An antibody that confers plant disease resistance targets a membrane-bound glyoxal oxidase in Fusarium. New Phytologist, 2016, 210(3): 997-1010.

4. He, W.-J., Yuan, Q.-S, Zhang, Y.-B., Guo, M.-W., Gong, A,-D., Zhang, J.-B., Wu, A.-B., Huang, T., Qu, B., Li, H.-P., Liao, Y.-C. Aerobic de-Epoxydation of trichothecene mycotoxins by a soil bacterial consortium isolated using in situ soil enrichment. Toxins, 2016, 8, 277.

5. Cheng, W., Song, X.-S., Li, H.-P., Cao, L.-H., Sun, K., Qiu, X.-L., Xu, Y.-B., Yang, P., Huang, T., Zhang, J.-B., Qu, B., Liao, Y.-C. Host-induced gene silencing of an essential chitin synthase gene confers durable resistance to Fusarium head blight and seedling blight in wheat. Plant Biotechnology Journal, 2015, 13, 1335-1345.

6. Cheng, W., Li, H.-P., Zhang, J.-B., Du, H.-J., Wei, Q.-Y., Huang, T., Yang, P., Kong, X.-W., Liao, Y.-C. Tissue-specific and pathogen-inducible expression of a fusion protein containing a Fusarium-specific antibody and a fungal chitinase protects wheat against Fusarium pathogens and mycotoxins. Plant Biotechnology Journal, 2015, 13: 664-674.

7. Gong, A,-D., Li, H.-P., Shen, L., Zhang, J.-B., Wu, A.-B., He, W.-J., Yuan, Q.-S., He, J.-D., Liao, Y.-C. The Shewanella algae strain YM8 produces volatiles with strong inhibition activity against Aspergillus pathogens and aflatoxins. Frontiers in Microbiology, 2015, Oct 6. doi: 10.3389/fmicb.2015.01091.

8. Hu, Z.-Q., Li, H.-P., Wu, P., Li, Y.-B., Zhou, Z.-Q., Zhang, J.-B., Liu, J.-L., Liao, Y.-C*. An affinity improved single-chain antibody from phage display of a library derived from monoclonal antibodies detects fumonisins by immunoassay. Analytica Chimica Acta, 2015, 867: 74-82.

9. Gong, A.-D., Li, H.-P., Yuan, Q.-S., Song, X.-S., Yao, W., He, W.-J., Zhang, J.-B., Liao, Y.-C. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliquefaciens S76-3 from wheat spikes against Fusarium graminearum. PLoS ONE, 2015 Feb 17;10(2): e0116871.

10. Song, X.-S., Li, H.-P., Zhang, J.-B., Song, B., Huang, T., Du, X.-M., Gong, A.-D., Liu, Y.-K., Feng, Y.-N., Agboola, R.S., Liao, Y.-C. Trehalose 6-phosphate phosphatase is required for development, virulence and mycotoxin biosynthesis apart from trehalose biosynthesis in Fusarium graminearum. Fungal Genetics and Biology, 2014, 63: 24-41.

11. Wang, J.-H., Li, H.-P., Zhang, J.-B., Wang, B.-T., Liao, Y.-C. First report of Fusarium maize ear rot caused by Fusarium kyushuense in China . Plant Disease, 2014, 98: 279-280. DOI: 10.1094/PDIS-05-13-0558-PDN.

12. Xue, S., Li, H.-P., Zhang, J.-B., Liu, J.-L., Hu, Z.-Q., Gong, A.-D., Huang, T., Liao, Y.-C. Chicken single-chain antibody fused to alkaline phosphatase detects Aspergillus pathogens and their presence in natural samples by direct sandwich enzyme-linked immunosorbent assay. Analytical Chemistry, 2013, 85, 10992-10999.

13. Song, B., Li, H.-P., Zhang, J.-B., Wang, J.-H., Gong, A.-D., Song, X.-S., Chen T., Liao, Y.-C. Type II myosin gene in Fusarium graminearum is required for septation, development, mycotoxin biosynthesis and pathogenicity. Fungal Genetics and Biology, 2013, 54: 60-70.

14. Hu, Z.-Q., Li, H.-P., Zhang, J.-B., Huang, T., Liu, J.-L., Xue, S., Wu, A.-B., Liao, Y.-C. A phage-displayed chicken single-chain antibody fused to alkaline phosphatase detects Fusarium pathogens and their presence in cereal grains. Analytica Chimica Acta, 2013, 764: 84-92.

15. Gao, C.-S., Kou, X.-J., Li, H.-P., Zhang, J.-B., Saad, A. Sefyan I., Liao, Y.-C. Inverse effects of Arabidopsis NPR1 gene on fusarium seedling blight and fusarium head blight in transgenic wheat. Plant Pathology, 2013, 62: 383-392.

16. Liu, Z.-W., Li, H.-P., Cheng, W., Yang, P., Zhang, J.-B., Gong, A.-D., Feng, Y.-N., Fernando, W. G. D., Liao, Y.-C. Enhanced overall resistance to Fusarium seedling blight and Fusarium head blight in transgenic wheat by co-expression of anti-fungal peptides. European Journal of Plant Pathology, 2012, 134: 721-732.

17. Hu, Z.-Q., Liu, J. L., Li, H.-P., Xing, S., Xue, S., Zhang, J.-B., Wang, J.-H., Nölke, G., Liao, Y.-C. Generation of a highly reactive chicken-derived single-chain variable fragment against Fusarium verticillioides by phage display. International Journal of Molecular Sciences,2012, 13, 7038-7056.

18. Ndoye, M., Zhang, J-B., Wang, J.-H., Gong, A.-D, Qu, B., Li, H.-P., Li, S.-J, Liao, Y.-C. Nivalenol and 15-acetyldeoxynivalenol chemotypes of Fusarium graminearum clade species are prevalent on maize throughout China . Journal of Phytopathology, 2012, 160: 519-524.

19. Wang, J.-H., Zhang, J-B., Chen, F.- F., Li, H.-P., Ndoye M., Liao, Y.-C. A multiplex PCR assay for genetic chemotyping of toxigenic Fusarium graminearum and wheat grains for 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol and nivalenol mycotoxins. Journal of Food, Agriculture and Environment. 2012, 10: 505-511.

20. Liu, J.-L., Hu, Z.-Q., Xing, S., Xue, S., Li, H.-P., Zhang, J.-B., Liao, Y.-C. Attainment of 15-fold higher affinity of a Fusarium-specific single-chain antibody by directed molecular evolution coupled to phage display. Molecular Biotechnology, 2012, 52: 111-122.

21. Liu, G., Han, Z., Nie, D., Yang, J., Zhao, Z. H., Zhang, J. B., Li, H.P., Liao, Y. C., Song, S., Saeger, S. D., Wu, A. B. Rapid and sensitive quantitation of zearalenone in food and feed by lateral flow immunoassay. Food Control, 2012, 27: 200-205.

22. Han, Z., Zhao, Z.-Y., Song, S.-Q., Liu, G., Shi, J.-X., Zhang, J.-B., Liao, Y.-C., Zhang, D.-B., Saeger, S. D., Wu, A.-B. Establishment of a model isotope dilution LC-MS/MS method revealing kinetics and distribution of co-occurring mycotoxins in rat. Analytical Methods, 2012, 4, 3708–3717.

23. Wang, J.-H., Ndoye, M., Zhang, J.-B., Li, H.-P., Liao, Y.-C. Population structure and genetic diversity of the Fusarium graminearum species complex. Toxins, 2011, 3, 1020-1037.

24. 宫安东,孔宪巍,翟新可,路亚南,文淑婷,张静柏. 枯草芽胞杆菌WY8-7的溶磷、抑菌及促生长作用. 南京农业大学学报,2019424):697-705

25. 何伟杰,刘易科,朱展望,张静柏,高春保,廖玉才. 镰刀菌毒素脱氧雪腐镰刀菌烯醇脱毒菌及脱毒酶研究进展. 植物病理学报,2019495):577-589

26. 胡祖权,李和平,张静柏,刘锦龙,廖玉才. 伏马菌素B1特异单链抗体的同源建模及分子对接模拟研究. 免疫学杂志,2015317):618-622


教材与著作

1. 《普通遗传学实验》参编,2015,高等教育出版社

2. 《遗传学》(第三版),参编,2015,科学出版社

3. 《植物生物技术》(第二版),参编,2012,科学出版社


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